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Polynucleotides for Facial Rejuvenation- Brand New Collagen Stimulator


Polynucleotides, the natural building blocks of nucleic acids like DNA and RNA, are emerging as a groundbreaking solution in the field of aesthetic medicine. Their ability to enhance tissue regeneration, improve skin quality, and deliver superior aesthetic outcomes has made them a popular choice for facial rejuvenation treatments. This article will delve into the key benefits of polynucleotides in skincare, provide clinical evidence, highlight popular polynucleotide-based products, discuss potential side effects and aftercare, and explore how they can be combined with other treatments for optimal results.

Mechanisms of Polynucleotide-Based Injectables

The basic unit of the polynucleotide-based injectable relies on long chains of highly purified nucleotides, which form a series of highly stable alpha helixes. These hypoallergenic polynucleotides are contained within a non-hyaluronic acid clear gel carrier.

Once injected intra-dermally, the high-purity polynucleotides target the dermal fibroblast to reduce levels of local free radicals, increase the synthesis of collagen and elastin appreciably, increase hydration through attracting water molecules local to the injection site, and increase the viability of the targeted fibroblasts (Colangelo et al., 2021).

Key Benefits of Polynucleotides in Skincare

Cellular Repair and Regeneration

Polynucleotides stimulate the repair of damaged cells and promote the regeneration of new ones. This cellular activity leads to improved skin texture and a reduction in fine lines. By enhancing the skin’s natural repair mechanisms, polynucleotides help to maintain a youthful and healthy appearance.

Anti-inflammatory Properties

One of the notable benefits of polynucleotides is their anti-inflammatory properties. They help soothe irritated skin, reduce redness, and improve conditions like acne and rosacea. This makes them an excellent choice for individuals with sensitive or problematic skin.

Hydration and Elasticity

Polynucleotides enhance the skin’s ability to retain moisture, resulting in plumper and more elastic skin. Improved hydration leads to a healthier skin barrier, which is essential for maintaining skin resilience and softness.

Collagen Production

By stimulating fibroblasts, polynucleotides increase collagen levels in the skin. Collagen is a crucial protein that provides structure and firmness to the skin. Enhanced collagen production leads to firmer, more youthful-looking skin, reducing the appearance of wrinkles and sagging.

Wound Healing

Polynucleotides possess regenerative properties that accelerate wound healing and reduce the appearance of scars. Their ability to promote tissue repair makes them valuable in treating various skin imperfections and enhancing overall skin quality.

Clinical Evidence

Recent studies have demonstrated significant improvements in skin hydration, elasticity, and overall appearance after treatment with polynucleotide-based products. However, it is important to note that research is still in its early stages, and more rigorous studies are needed to validate these findings and ensure patient safety.

Popular Polynucleotide-Based Skincare Products


Nucleofill is renowned for its regenerative properties, helping to improve skin elasticity and hydration. It is a popular choice for individuals seeking a non-invasive solution to enhance skin quality especially around eye area.


Often referred to as the “skin healer,” Rejuran is widely used in Asia for its ability to repair damaged skin and enhance overall skin texture. It is particularly effective in treating fine lines, wrinkles, and acne scars.


PhilArt polynucleotide products are designed to boost collagen production and improve skin firmness. These products are ideal for individuals looking to achieve a more youthful and lifted appearance.

Crystal PDRN

Crystal PDRN is used for skin rejuvenation and scar correction, leveraging the benefits of polynucleotides to promote healthier skin. It is a versatile product that addresses various skin concerns.

Pluryal Silk

Pluryal Silk is an injectable treatment that enhances skin quality by stimulating cellular repair and regeneration. It is commonly used to improve skin texture, hydration, and elasticity.

Potential Side Effects

Polynucleotides are generally well-tolerated, but like any injectable treatment, they can have some side effects. Here are the most common ones:

1. Redness and Swelling: These are typical reactions at the injection site and usually subside within a few days.

2. Bruising: Minor bruising can occur due to needle insertion.

3. Tenderness and Itching: Some individuals might experience mild tenderness or itching around the treated area.

4. Allergic Reactions: Although rare, allergic reactions can occur.

5. Infection: As with any injection, there is a small risk of infection.

Most side effects are temporary and resolve on their own. It’s always best to consult with a qualified healthcare provider to discuss any potential risks and ensure the treatment is suitable for you.

Aftercare Guidelines

After receiving a polynucleotide treatment, it’s important to follow certain precautions to ensure optimal results and minimize any potential side effects. Here are some key guidelines:

1. Avoid Touching the Treated Area: Refrain from touching or applying pressure to the treated areas for at least 24 hours.

2. Stay Hydrated: Drink plenty of water to help your skin heal and stay hydrated.

3. Avoid Strenuous Exercise: Avoid strenuous exercise and exposure to heat, such as saunas or hot tubs, for 48 hours.

4. Sun Protection: Use a broad-spectrum sunscreen daily, ideally SPF 30 or higher, and avoid direct sun exposure.

5. Avoid Active Skincare Ingredients: Keep your skincare routine simple and gentle for the first 48-72 hours. Avoid products with active ingredients like retinoids, AHAs, and acids.

6. Avoid Makeup: It’s generally recommended to avoid applying makeup for the first 24 hours after treatment.

Following these precautions can help ensure a smooth recovery and enhance the effectiveness of your treatment.

Timeline of Results

After a polynucleotide treatment, you can expect to see some initial improvements within the first few weeks. However, the full benefits typically become more noticeable after about 12 weeks. This is because polynucleotides work on a cellular level, promoting gradual skin regeneration and collagen production.

Timeline of Results:

– First Few Weeks: Initial improvements in skin hydration and texture.

– 4-6 Weeks: More noticeable changes in skin elasticity and firmness.

– 12 Weeks: Full benefits, including smoother, brighter, and more lifted skin.

It’s important to follow the recommended aftercare and possibly undergo multiple sessions to achieve the best results.

Combining Polynucleotide Treatments with Other Aesthetic Treatments

Yes, you can combine polynucleotide treatments with other aesthetic treatments to enhance overall results. Here are some common combinations:

1. Dermal Fillers: Combining polynucleotides with hyaluronic acid fillers can provide immediate volume and hydration while promoting long-term collagen production and skin quality improvement.

2. Microneedling: This combination can enhance the absorption and effectiveness of polynucleotides, leading to better skin texture and rejuvenation.

3. Laser Treatments: Pairing polynucleotides with laser treatments can improve skin tone, texture, and elasticity by targeting different layers of the skin.

4. Radiofrequency (RF) Treatments: RF treatments can be combined with polynucleotides to tighten and firm the skin, enhancing the overall rejuvenation effect.

5. Chemical Peels: Using polynucleotides after a chemical peel can help soothe the skin and accelerate the healing process, leading to improved results.


Polynucleotides represent a promising advancement in the field of facial rejuvenation. Their ability to promote cellular repair and regeneration, reduce inflammation, enhance hydration and elasticity, stimulate collagen production, and accelerate wound healing makes them a valuable addition to modern skincare treatments. By choosing polynucleotide-based products and following proper aftercare, you can achieve significant improvements in your skin’s appearance and health. For those looking to combine treatments for enhanced results, consulting with a qualified aesthetic professional can help create a tailored plan to meet your skincare goals.