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Nucleofill- New Injectable Treatment for Skin Rejuvenation


Hong Kong LM SKINCENTRE introduces the new Nucleofill injection. Nucleofill is an injectable gel made from polymerized polynucleotides (PDRN) of animal (fish) origin. It’s used in aesthetic medicine for its moisturizing, antioxidant properties, and ability to create an optimal environment for fibroblast growth and tissue elasticity restoration.

How Does Nucleofill Work?

Nucleofill operates on three levels:

1. Skin Lifting: It contains polynucleotides that stimulate fibroblast receptors, leading to the formation of elastin and type-one collagen. This improves skin elasticity.

2. Antioxidant Effect: The polynucleotides eliminate free radicals, reducing oxidative stress in the skin.

3. Skin Hydration: Nucleofill binds water molecules at the cellular level, providing long-lasting hydration.

Indications for Nucleofill

Nucleofill is indicated for the temporary correction of minor skin defects, including:

– Tear trough

– Very shallow lines and superficial wrinkles, including the delicate eye area

– Small scars

– Improvement of skin elasticity, firmness, and hydration

It is also used for treating fibrotic changes like scars and for combating signs of aging and photoaging.

Contraindications for Nucleofill

Nucleofill should not be used in patients with:

– Hypersensitivity to any of its components

– Active infections or inflammation in the treatment area

– Autoimmune diseases

– Pregnancy or breastfeeding

Mechanism of Action of Nucleofill

The mechanism of action of Nucleofill is attributed to its unique composition of polynucleotides (PN), which:

– Stimulate fibroblast receptors, leading to improved skin elasticity by promoting the formation of elastin and type-one collagen

– Provide antioxidant effects by eliminating free radicals and reducing oxidative stress in the skin

– Bind water molecules at the cellular level for long-lasting hydration, creating an optimal environment for fibroblast growth and tissue elasticity restoration

Who is Suitable for Nucleofill Injections?

Nucleofill is ideal for individuals with hypoxic, dehydrated, or oxidatively stressed skin. It’s particularly effective for those seeking to improve skin elasticity, reduce fine lines and wrinkles, and achieve tighter, more moisturized skin.

FAQ About Nucleofill

Q: What are the differences between Nucleofill products?

A: Nucleofill comes in three variants:

– Nucleofill Eye: For very delicate areas around the eyes.

– Nucleofill Medium: For deeper wrinkles and medium-sized scars.

– Nucleofill Strong: For deep wrinkles and extensive scars.

Q: What are the side effects of Nucleofill?

A: Common side effects include swelling, bruising, or discoloration at the injection site. These usually subside within a few hours to days.

Q: How is Nucleofill injected?

A: Nucleofill can be injected using various techniques such as linear, point, cross-linked, or fan-shaped injections. It’s crucial to have a qualified doctor perform the injections.

Q: What is the downtime for Nucleofill treatment?

A: Patients may experience mild redness and swelling for 1-3 days. Same as all injectables, there may be bruising that last for few days. Most people feel comfortable returning to regular activities the next day. Optimal improvement is seen after 3 monthly sessions.

Q: How does Nucleofill compare to Hyaluronic Acid Fillers?

A: Unlike HA fillers that provide immediate volume, Nucleofill stimulates the skin’s repair and regeneration from within. It can be combined with HA fillers for both volumizing and regenerative effects.

Q: What is the price for Nucleofill injection?

A: The price would depends on the Nucleofill products you choose and the volume you need to inject. You can contact us to learn more.