In the pursuit of health and youth, extending lifespan has become a popular topic of concern for modern individuals. As we age, it’s inevitable to feel changes in our bodies, and how to cope with aging has become an enduring question for many.
Aging is a natural process, but its causes are complex, primarily related to the generation of free radicals and oxidative processes. These factors gradually lead cells toward apoptosis. Changes in DNA due to external environmental stimuli can affect protein synthesis, which may be a key factor in aging. Over time, DNA damage gradually accumulates, ultimately forming aging-related genes.
This book also discusses certain medications that may influence the aging process, such as Metformin, Rapamycin, and nicotinamide riboside (a NAD precursor). Research has shown that these drugs possess potential anti-aging effects. One of the mechanisms of these substances is to initiate corresponding biochemical reactions by removing certain molecular modifications. Studies conducted over 20 years ago indicated that these medications have good energy supply capabilities and relatively low side effects, leading to their popularity in the market.
Currently, Metformin is primarily used for treating diabetes and polycystic ovary syndrome, and it has shown significant benefits in weight control. However, maintaining health through medication always requires professional guidance, as even the relatively mild side effects of Metformin can include risks such as hypoglycemia. The use of Metformin by healthy individuals should be approached cautiously regarding dosage and carried out under medical advice to avoid arbitrary misuse.
For those seeking health and longevity, adjustments in lifestyle are equally crucial in addition to potential medications. Reducing calorie intake, adopting intermittent fasting, and exercising regularly are effective methods. In terms of exercise, higher-intensity activities, such as running or cold therapy, offer more health benefits. These methods not only help control weight but also improve overall health and lower the risk of chronic diseases.
Aside from diet and exercise, the medical community has also discovered a close relationship between oxidative reactions and chronic diseases. Excessive sugar intake can lead to the formation of advanced glycation end products (AGEs), which interfere with cellular repair mechanisms and increase the risk of aging and inflammatory diseases. Recent studies have also suggested that Metformin, as a first-line treatment for diabetes, has potential to reduce inflammation and improve overall health, possibly playing a role in delaying aging.
Finally, through the advancements of various studies, we have gained a more comprehensive understanding of anti-aging. When facing the challenges of aging, maintaining health and adopting a proactive attitude may be beliefs each of us should uphold. I hope everyone can find their own methods in the journey against aging and live each day to the fullest!