Pluryal Silk is a cutting-edge skin treatment now available to dermatology patients in Hong Kong. It utilizes highly pure polynucleotides (PNs) – DNA fragments derived from salmon – to naturally repair and revitalize skin. Unlike traditional dermal fillers, Pluryal Silk acts as a collagen stimulator, encouraging your skin to regenerate and heal from within. This innovative injectable is the first in the world with CE approval exclusively for use around the eye area, attesting to its safety and efficacy for treating dark circles, fine lines, and thinning skin in the eye area.
What Is Pluryal Silk?
Pluryal Silk is a polynucleotide intradermal gel (2ml syringe) developed specifically for delicate facial skin. It’s part of the Pluryal “Beauty Densifiers” series from Europe, which uses a patented HPN (Highly Pure Polynucleotide) technology. This HPN technology involves extracting DNA fragments from salmon and purifying them at high temperature to create a highly pure PN gel that is very similar to human DNA. In fact, salmon DNA shares about 98% genetic similarity with human DNA, resulting in excellent biocompatibility with human skin. The end product is a medical-grade polynucleotide gel with a unique three-dimensional support structure, manufactured in Europe under strict pharmaceutical standards (CE certified) for safety and quality.
Key Features of Pluryal Silk:
- Designed for the Eye Area: Pluryal Silk was developed for the fragile, sensitive skin around the eyes. It has the ideal viscosity and particle size to be safely injected into thin skin without causing lumps. In fact, it’s the only Pluryal product specialized for the eye region, whereas other Pluryal products target broader areas (e.g. Pluryal Densify for the full face).
- High-Purity Polynucleotides: The main ingredient is highly pure polynucleotide (PN) derived from salmon DNA. This purity maximizes efficacy and minimizes any allergy risk. The PN acts as a bioactive molecule that stimulates skin regeneration.
- Biocompatible and Safe: With its DNA so closely mirroring our own, Pluryal Silk’s PN gel is highly biocompatible. It’s been CE-certified in Europe specifically for the delicate eye area, reflecting a strong safety profile. It contains no synthetic chemicals or cross-linked fillers – just naturally derived DNA segments and a hydrating hyaluronic acid base, making it very well-tolerated by skin.
How Does Pluryal Silk Work?
Pluryal Silk works by delivering highly purified polynucleotides into the dermis, where they jump-start the skin’s own repair and rejuvenation processes. Polynucleotides (PN) are DNA fragments that have several beneficial effects when introduced into the skin:
- Collagen Stimulation: Once injected, the PNs stimulate fibroblast cells – these are the cells that produce collagen and elastin. By promoting fibroblast activity, Pluryal Silk increases the skin’s collagen density and elastin fibers, leading to firmer, more elastic skin over time. Clinical studies showed a significant increase (about 7%) in total collagen by just day 9 after PN injection, highlighting its powerful collagen-inducing effect.
- Deep Hydration and Plumping: The PN gel is formulated with hyaluronic acid and has high water-binding capacity. It attracts and retains moisture in the skin, improving hydration levels and “plumping” the tissue from within. One study reported roughly a 30% increase in skin moisture content after PN treatment. This hydration smooths out fine crepey lines and gives skin a dewy, healthy look.
- Tissue Repair and Regeneration: Polynucleotides support the skin’s natural healing. They encourage cell regeneration and DNA repair, helping skin cells recover from UV damage and environmental stress. Essentially, PNs provide the building blocks for cells to repair themselves, which is why Pluryal Silk can “repair the skin’s metabolism” (the skin’s renewal processes).
- Anti-Inflammatory & Calming: PNs have been found to reduce inflammation in the skin. They neutralize free radicals and calm inflammatory processes, which is especially beneficial for sensitive or redness-prone skin (for example, those with rosacea, eczema or post-acne redness). By reducing chronic inflammation, the skin can heal and improve without irritation.
- Improved Microcirculation: An interesting effect of PN therapy is that it can stimulate angiogenesis – the formation of new blood vessels. Better blood circulation means improved nutrient delivery and toxin removal in the treated area. Around the eyes, this enhanced microcirculation helps fade dark circles by addressing one root cause (poor blood flow).
- Antioxidant Protection: Polynucleotides also provide antioxidant effects, scavenging free radicals that cause skin aging. This protective effect can slow down the appearance of new aging signs.
By combining all these mechanisms, Pluryal Silk revitalizes the skin from the inside out. The treatment leads to gradual, natural improvement in skin quality: increased elasticity, better hydration, smoother texture, and a more even tone. Patients typically notice that their skin in the treated area becomes firmer, plumper, and healthier in the weeks following injections, as the collagen matrix rebuilds and the tissue regenerates.
Targeted for the Eye Area: Because of its multi-faceted regenerative action, Pluryal Silk is particularly effective for the notoriously tricky eye region. Prior to PNs, issues like under-eye dark circles and fine lines were very hard to treat without surgery or fillers. Pluryal Silk’s unique actions (especially collagen boosting and angiogenesis) help thicken the thin under-eye skin and improve circulation, thereby reducing the appearance of dark circles and hollowing. Its anti-inflammatory nature is gentle for sensitive eyelid skin, and the hydration it provides improves crepey texture around the eyes. This is a major advancement for eye rejuvenation, achieving improvements that standard hyaluronic acid fillers or creams alone often cannot.
Key Benefits of Pluryal Silk
Pluryal Silk offers a wide range of skin benefits, making it a versatile treatment. Patients in Hong Kong often seek this treatment to address concerns such as tired-looking eyes, fine wrinkles, or dull skin. Here are the key benefits you can expect from Pluryal Silk:
- Brightens Dark Circles: By thickening the under-eye skin and boosting circulation, Pluryal Silk helps diminish dark under-eye circles. It brightens the eye contour, making you look more rested and youthful. The improved blood flow and DNA repair reduce pigmentation and shadowing under the eyes.
- Smooths Fine Lines & Wrinkles: This collagen stimulator injection restores lost collagen in delicate areas, thereby smoothing out fine lines around the eyes (crow’s feet) and mouth. Skin becomes more supple and lines are less visible as new collagen fills them in over the weeks following treatment.
- Improves Skin Texture & Pores: Patients often notice refined skin texture and smaller pores after a course of Pluryal Silk. The treatment boosts cellular turnover and repair, which helps tighten enlarged pores and smooth rough skin. Overall skin tone and texture become more even, giving a radiant complexion.
- Deep Hydration for Dry, Dull Skin: The polynucleotide-hyaluronic gel intensely hydrates the skin from within. Pluryal Silk improves skin hydration and softness, alleviating dryness and dullness. Well-hydrated skin not only looks healthier but also functions better as a barrier.
- Enhanced Elasticity & Firmness: By promoting elastin and collagen production, Pluryal Silk boosts skin elasticity and firmness. Treated skin becomes bouncier and more resilient. Patients often report that their skin “feels tighter” yet soft, and clinical data show significant increases in skin suppleness after treatment.
- Calms Sensitive or Redness-Prone Skin: Pluryal Silk is suitable for fragile, sensitive skin that may not tolerate aggressive treatments. Its anti-inflammatory effects can soothe chronic redness or irritation (for example, around the eyes or on cheeks with acne scars). The gentle formulation (free of cross-linked synthetic chemicals) is ideal for those with sensitive skin who still want noticeable rejuvenation.
- Scar and Stretch Mark Improvement: An added benefit is that the collagen-regenerating property can help improve acne scars and stretch marks. In fact, Pluryal Silk is sometimes used on areas like acne-scarred cheeks or postpartum abdominal stretch marks to repair skin texture. Over a series of treatments, scars can appear smoother and less visible.
All these benefits combine to reduce the true age of your skin, giving a naturally refreshed and youthful look. By treating not just one issue but the overall quality of the skin (hydration, texture, firmness, tone), Pluryal Silk provides a comprehensive rejuvenation – especially for the delicate eye area and other zones of thin, aging skin.
Pluryal Silk vs. Pluryal Densify: What’s the Difference?
Pluryal Silk is one of two main polynucleotide injectables in the Pluryal Densifiers range – the other is Pluryal Densify. Both use the same HPN polynucleotide technology, but they are formulated for different purposes and treatment areas. Here’s a short comparison to understand when one might be more appropriate than the other:
- Target Areas: Pluryal Silk is specialized for fine, delicate areas. It is recommended for the eye area (under and around the eyes), the upper eyelids, and even around the lips. It’s also suitable for other thin-skin regions like the neck, inner arms, décolletage, or stretch marks on the abdomen. In contrast, Pluryal Densify is designed for larger or deeper facial areas. It is typically used in the face (cheeks, temples, etc.) but not under the eyes, as it’s a heavier formulation. Densify is great for addressing general facial skin aging, whereas Silk “targets the gaps” in areas Densify can’t treat (like the eyelids or under-eye).
- Skin Concerns: Silk is ideal for early to moderate signs of aging – think fine lines, mild skin laxity, dark circles, and superficial acne scars. It’s often chosen for those with sensitive or thinner skin who need a gentle touch. Densify, on the other hand, is formulated for more mature skin changes. It’s used to treat deep wrinkles (e.g. nasolabial folds, marionette lines) and deeper scars or significant skin sagging. If your skin has started to lose significant elasticity or has deep-set lines, Densify might be recommended to rebuild the support structure in those areas.
- Injection Depth & Composition: Pluryal Silk is injected into the mid to deep dermis of delicate areas, using a very fine needle or cannula around the eyes or lips. It has a slightly lighter texture appropriate for superficial injection without lumpiness. Densify is injected into the deep dermis of the skin, indicating it’s a bit thicker to work in deeper layers. Both contain PN and a hyaluronic gel, but Densify may have a higher concentration or viscosity to better fill and firm larger zones.
- When to Choose Which: In practice, your doctor will recommend Silk for eye rejuvenation and fine detail work, and Densify for broader facial rejuvenation. They can even be used complementarily – for example, a patient might get Pluryal Silk for under-eye circles and Pluryal Densify for the cheeks or forehead wrinkles, ensuring each area gets the appropriate treatment. If the primary concern is dark circles, eye bags, or fine periocular wrinkles, Pluryal Silk is the go-to choice. If the concern is overall facial volume loss, deep nasolabial folds, or general skin quality in an older skin, Densify could be more suitable.
In summary, Pluryal Silk vs. Densify comes down to delicate vs. deep. Silk is a specialist for delicate, sensitive skin and superficial issues (especially around the eyes), while Densify is a workhorse for deeper wrinkles and global anti-aging on the face. Both are safe and effective collagen stimulators – the choice depends on the treatment area and aging severity.
Treatment Details: Areas, Sessions, Safety, and Aftercare
In this section, we outline practical details about getting a Pluryal Silk treatment – including where it’s injected, how often treatments are done, safety considerations, and what to expect after the procedure.
Treatment Areas and Injection Procedure
Recommended Injection Areas: The hallmark of Pluryal Silk is treating the eye area. Common injection sites include the under-eye region (tear troughs and eye bags), the crow’s feet area, and even the upper eyelids and brow area for crepey skin. It can also be injected at the outer corners of eyes and under the eyebrows to address fine lines. Aside from eyes, doctors may use Silk around the mouth (lip lines) and on the neck for fine wrinkles. Off-label, Silk has been used on acne-scarred areas or any localized patch of sensitive, thin skin that needs regeneration (for example, a small scar on the face).
Injection Technique: Pluryal Silk comes in a pre-filled 2ml syringe. A very fine needle or micro-cannula is used to inject small amounts of the PN gel into the dermis of the target area. For under-eye injections, your doctor will typically use a cannula or a series of micro-injections to distribute the product evenly and safely. The procedure is relatively quick – injecting both under-eye areas and adjacent regions can be done in about 20-30 minutes. A topical numbing cream is often applied beforehand to ensure you’re comfortable. Most patients report minimal pain (just a slight pressure or pinch), since the needle is extremely fine and the injection is shallow.
During the injection, the practitioner will place the product in the mid- to deep-dermis, depending on the issue. For example, to treat dark circles, the PN gel might be laid just above the orbital bone (deep dermis), whereas to smooth fine lines at the surface, it might be placed more superficially. Because the product is soft and flows easily, it integrates into the skin without forming hard lumps. Pluryal Silk’s formulation is tailored for these delicate areas – it has the right thickness to stay in place yet spread nicely in thin skin.
Number of Sessions and Frequency
Initial Treatment Regimen: For optimal results, Pluryal Silk is usually done as a series of treatments rather than a one-time injection. A typical protocol starts with 3 to 4 treatment sessions spaced about 2–3 weeks apart. Spreading the sessions out allows each injection to gradually build upon the last – stimulating new collagen and improving skin quality incrementally. Many patients notice some improvement even after the first session (especially in hydration and glow), but the most significant changes (reduction in wrinkles, dark circles, etc.) occur after completing a few sessions over a couple of months.
Maintenance Treatments: The rejuvenating effects of Pluryal Silk aren’t permanent – your skin will continue to age, though at a hopefully slower pace thanks to the treatment. Generally, results last around 6 to 12 months before gradually diminishing. To maintain the benefits, maintenance sessions are recommended roughly once every 6 to 12 months. Some doctors suggest a single “touch-up” injection every 6 months; others may advise an annual session. If you have a special concern (for instance, your dark circles tend to come back quicker), you might do minor touch-ups in that area more frequently. Regular maintenance keeps the collagen stimulation ongoing so that improvements are sustained long-term.
Every patient’s skin is different – younger patients might maintain results longer, whereas those with more sun damage might metabolize the product faster. Your doctor will personalize the schedule. The good news is that even if you stop treatments, you won’t “lose” everything overnight – your skin will simply gradually return to its baseline over time, but it will be better than if you had never done the treatments (thanks to the collagen that was built).
Safety and Side Effects
Certified Safety: Pluryal Silk has a strong safety profile backed by European CE certification. Because the polynucleotides are highly purified and biologically compatible (remember the 98% similarity to human DNA), allergic reactions are extremely rare. There are no animal proteins or harsh chemicals in the product – it’s essentially a refined DNA gel. This makes it suitable even for individuals with sensitive skin or those who’ve had reactions to other injectables. In fact, Pluryal Silk’s development focused on creating a product gentle enough for the delicate eye region where other treatments might be too risky.
Common Side Effects: As with any injection, you can experience mild, temporary side effects at the injection site. The most common are redness, swelling (puffiness), tenderness, or minor bruising in the treated area. For instance, after under-eye injections, you might have some puffiness or a “pinky” hue under the eyes for a day. These reactions typically subside within 24 to 48 hours. If a tiny blood vessel is nicked and bruising occurs, the bruise could take up to a week or two to fully fade, but can usually be covered with makeup after the first day.
Minimizing Risks: In experienced hands, the procedure is very safe. Your doctor will use techniques to minimize bruising, such as using a blunt cannula or very fine needles and applying gentle pressure. At our LM SKINCENTRE, we take precautions like thorough medical screening (to ensure you’re not on any blood thinners that could increase bruising) and proper sterilization. The amount of product used is controlled to avoid overfilling. No skin test is required before Pluryal Silk because the ingredients are not known to cause allergic reactions in humans – again, due to the high purity and biocompatibility of the PNs.
Overall, Pluryal Silk is considered a very safe procedure with minimal downtime and side effects. Serious complications are exceedingly rare when the treatment is performed by a qualified medical professional. Always ensure you are treated by a licensed doctor or aesthetic doctor familiar with polynucleotide injections for the safest outcome.
Post-Treatment Care and Expectations
One advantage of Pluryal Silk for busy patients is the minimal downtime. You can typically return to normal daily activities immediately after treatment, with just a few precautions:
- Immediate Aftercare: You may be advised to apply ice packs gently to the treated area right after injection to reduce swelling.
- Same Day: Avoid strenuous exercise, heavy sweating, or bending over excessively on the day of treatment – this helps minimize swelling and bruising. Also avoid alcohol on the same day, as it can increase bruising risk.
- No Heat or Saunas: For about a week after your injection, it’s best to avoid very hot environments like saunas, steam rooms, or hot baths. Heat can exacerbate swelling or cause the injected PN to diffuse more than desired.
- Hands Off: Refrain from rubbing or massaging the treated area for a few days (unless instructed by your doctor). The injection sites might be a little tender, so be gentle when cleansing your face. Also, avoid applying makeup for at least 24 hours to keep the area clean.
- Skincare: Continue with gentle skincare and ample hydration. Your doctor may recommend using mild, soothing products (like arnica gel for bruises or a gentle moisturizer). Always apply sunscreen if you’re going outdoors, especially if you have any bruising (to prevent pigmentation in the healing bruise).
What to Expect in the Days and Weeks After: Immediately after the injections, you might feel a subtle tightness or fullness in the area – some patients say their under-eye area feels “filled” or firmer right away. Within the first week, once initial swelling subsides, you’ll begin to see improvements in skin hydration and texture – the area may look more moisturized and slightly smoother. Over the next 2 to 4 weeks, the polynucleotides kickstart robust collagen production and cellular repair. Gradually, you’ll notice fine lines diminishing, skin becoming firmer, and dark circles lightening as the skin thickens with new collagen. By about 2–3 months post-treatment, the maximum results are visible – eyes look more rejuvenated, and the skin quality is markedly improved. This slow, natural improvement is a hallmark of biostimulatory treatments like Pluryal Silk (in contrast, fillers give an immediate change). Patients appreciate that the outcome looks very natural – you’ll simply appear more rested and youthful rather than having an obvious “done” look.
Frequently Asked Questions (FAQ)
Q1: Is Pluryal Silk safe?
A: Yes, Pluryal Silk is considered very safe when administered by a qualified physician. It is CE-certified and made with biocompatible polynucleotides, meaning the body readily accepts it with minimal risk of allergic reaction. The product is purified to pharmaceutical standards, and its main ingredient is DNA from salmon which is 98% similar to human DNA, ensuring high biocompatibility. Clinical use in Europe and Hong Kong has shown only mild side effects like temporary swelling or bruising, which resolve quickly. It does not contain any toxins or synthetic microspheres, so it does not carry risks like migration or nodules that some other injectables might have. As a precaution, Pluryal Silk is not recommended for pregnant or breastfeeding women (simply because it hasn’t been tested in those groups). Overall, for the general adult population looking to improve their eye area, Pluryal Silk is a safe and gentle option.
Q2: How is Pluryal Silk different from dermal fillers (hyaluronic acid fillers)?
A: Pluryal Silk and dermal fillers are both injectables but work in very different ways. Dermal fillers (like Juvederm or Restylane) are made of hyaluronic acid gel that instantly adds volume to fill in wrinkles or hollows. They are like “implanting” a gel to reshape an area. Pluryal Silk, on the other hand, is a biostimulator – a collagen stimulator rather than a volumizer. It does not immediately add significant volume or change face shape. Instead, it gradually improves skin quality by stimulating your skin’s own collagen, elastin, and repair processes. For example, under the eyes, Pluryal Silk will thicken the skin and improve dark circles over several weeks, whereas a filler will instantly fill a hollow tear trough. Another difference is longevity and naturalness: results from Pluryal Silk build up and can last 6-12 months or more, and they fade gradually without abrupt change. Fillers last until the gel dissolves (also around 6-12 months for eye fillers), but if too much is placed it can sometimes look puffy or cause a blue tint under the eyes. Pluryal Silk is much less likely to cause puffiness or lumpiness in the thin under-eye skin because it’s fluid and integrates into tissue. It also improves things fillers often can’t, such as skin texture, fine creases, and pigmentation (fillers don’t address skin texture or color at all). In summary, fillers are best for structural volume loss, while Pluryal Silk is best for skin rejuvenation. In fact, some patients do Pluryal Silk first to improve the baseline skin, and then use a small amount of filler if any hollow remains – this combined approach can yield a very natural eye rejuvenation result.
Q3: What should I do after the treatment? Is there any downtime or special care required?
A: Post-treatment care for Pluryal Silk is straightforward since downtime is minimal. Right after the injection, your doctor may give you an ice pack to reduce swelling. You should avoid rubbing or massaging the area that day and skip strenuous activities and alcohol until the next day. It’s also advised to avoid saunas, steam rooms, or very hot showers for about 7 days, as heat can increase swelling. If you got injections around the eyes, sleep with an extra pillow to keep your head slightly elevated the first night – this can help reduce any swelling. You can use light makeup the next day to cover any mild bruising if needed (there’s usually little to no bruising). Keep the skin clean and moisturized; follow any skincare instructions your doctor provided (often, using a gentle arnica cream or vitamin K cream can help bruises fade faster). Most people find they can resume work or normal life immediately or within a day after Pluryal Silk, as there is very little visible evidence of the procedure aside from possible mild redness. In short, downtime is minimal – just be gentle with the area and avoid intense activities for a short period. Within a week you’ll be enjoying the early benefits (like better hydration), and remember the full results will take a few weeks to become apparent.
Q4: Who is a good candidate for Pluryal Silk treatment?
A: Pluryal Silk is an excellent option for men or women who are looking to rejuvenate the eye area or other zones of fine, sensitive skin. Ideal candidates are those with concerns such as: dark under-eye circles, fine lines around the eyes or mouth, mild eyelid droop or crepey skin, enlarged pores or rough skin texture, or early loss of skin elasticity. It’s often recommended for individuals in their late 20s or 30s and above who are starting to notice aging signs and want to prevent or treat early wrinkles. People in their 40s, 50s, and 60s also see great results, especially if they have thinning skin or persistent dark circles that don’t improve with topical creams. Since it’s so gentle, Pluryal Silk is suitable for those with sensitive skin or who have had issues with other treatments. If you have chronic under-eye bags or hyperpigmentation, it can help improve those as well by building skin quality. However, if you have very deep under-eye hollows or extremely loose skin, sometimes a combination with other treatments (like fillers or surgery) might be needed – a doctor can assess this. Generally, anyone who desires a natural rejuvenation (versus a dramatic change) would be a good candidate. As noted earlier, you should not undergo Pluryal Silk if you are pregnant or breastfeeding, and if you have an active skin infection in the area, that should be treated first. Always consult with a licensed doctor in Hong Kong who can evaluate your specific condition and determine if Pluryal Silk is the right choice for you.
For those in Hong Kong looking to revitalize their eye area without aggressive surgery or artificial fillers, Pluryal Silk provides a scientifically advanced solution backed by clinical research and European safety certifications. Always consult with a qualified doctor to discuss your goals – with the right guidance, Pluryal Silk can help you achieve brighter, firmer, and more youthful skin around the eyes and beyond.