Today, let’s delve into the various options for topical retinoids, helping us find the most suitable beauty regimen to prevent those pesky acne scars. There are many retinoid products available on the market, with the most common ones being first-generation retinoids (scientific name Tretinoin), Epiduo, Epiduo Forte, and the newly launched fourth-generation retinoid Aklief (trifarotene). With so many choices, how should one select?
First, let’s understand the first-generation retinoid. As the oldest retinoid, it has been shown to be effective in treating acne, pigmentation, and signs of aging. Although it is the strongest in effect, the skin reactions after use can also be the most significant. These reactions may include redness, itchiness, or a stinging sensation, which I believe are not true side effects but rather a normal response of the skin to the medication. It is worth noting that due to its photosensitivity, it is recommended not to use this retinoid during the daytime to avoid sun exposure.
Moving on to the second-generation retinoid, which is Etretinate. This medication is no longer in use on the market.
Third-generation retinoids, such as Epiduo and Epiduo Forte, are photostable, meaning they can be used during the day without causing issues. Particularly, Epiduo Forte contains 0.3% Differin and 2.5% benzoyl peroxide (BPO), enhancing the treatment effect, especially suitable for inflammatory acne.
With advancements in medical technology, the fourth-generation retinoid trifarotene has emerged. This retinoid uses selective binding technology, theoretically leading to fewer side effects for the skin. However, based on my personal experience and that of my patients, the tolerance of trifarotene is just slightly better than that of the first-generation retinoids.
Ultimately, choosing the right retinoid depends on your skin type and treatment needs. Whether you go for the first, third, or fourth generation, as long as it effectively controls acne, it is a good choice. If you find that over-the-counter products are not effective, you may consider other options available in the market, such as Epiduo or trifarotene.
I also want to remind everyone pursuing perfect skin that if acne continues to be uncontrollable, it’s essential to seek assistance from a doctor. If necessary, stronger medications can be used, as timely treatment can effectively prevent the formation of future acne scars.